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Life Extension: The Modern Anti-Aging Movement – Are We Standing at the Threshold of Immortality?

July 17, 2016 by · Comments Off on Life Extension: The Modern Anti-Aging Movement – Are We Standing at the Threshold of Immortality?
Filed under: General 

Why is skincare the focus of longevity research? I guess a cell is a cell, and if you can crack the code for one human cell, it is only a matter of time to solving the puzzle with different types of cell – and skin is without doubt the most visible cells each of us have. And it’s our faces in particular we often judge ourselves and others by, and we are in turn quickly scrutinized, and often opinions reached in a fraction of a second. Our faces often show the most visible signs of aging, and for many in modern society age is by nature “bad” and young or looking young is the ideal. That is why billions and billions of dollars each year are poured by consumers into all sorts of treatments to minimize wrinkles, to push back the effects of gravity, and to turn back the hands of time. And with that much money to be spent by consumers, there are many manufacturers eager to find the next step in arresting Father Time – and at least detaining him until the next stagecoach arrives, where hopefully he can be encouraged to move on before too much damage can be done.

The Entire Issue Explained – In A Pair of Shoelaces

Some time ago a friend gave me a simple analogy that puts this entire issue in perspective. The science may not win a Nobel Prize, but it gave me the necessary ah-ha moment.

The double helix of the DNA strand – our most basic foundation for life – is held together at each end by things that act in the same way as the hard plastic bits on the end of shoelaces do – preventing the DNA from unraveling, and the individual chromosomes scattering across the floor like dropping a string of pearls down a marble staircase. These things are called telomeres.

Somewhere programmed into these tiny telomeres is the entire basis to how long the DNA stays intact – and by inference these are the keys to the length of life of the organism. Somewhere written into the telomere is a great musical score but like all musical scores it has a double bar somewhere to signify the end; but is it to be a minuet or a Wagnerian epic? But sure enough, when the time comes, and the telomeres blow the full time whistle, the DNA strand will unravel and die – and the circle of life begins again. Telomeres govern how often our skin cells are replaced; why a puppy and a child born on the same date may age exactly the same chronologically, but the puppy has become a geriatric before the child reaches puberty.

Telomeres, my friend explained, occasionally go on the fritz (that must have a very specific scientific meaning). One of the ways this occurs is they may forget their programming to release and unravel, and they just hang on, allowing the cells thus affected to multiply again and again without dying. In fact, when this occurs often they become very difficult to kill and to all intents and purposes once the telomeres act in this way, the cell – and those it propagates – are effectively immortal.

This condition has a name which we all know. Cancer.

But, what if we were able in some way to persuade the telomeres within a cancer to behave normally – would that not be the “magic bullet” cure for cancer? And the other side to that equation – if the telomeres in healthy cells could be persuaded to act as they do in a cancer – then is this the recipe for a healthy cell that does not die? Does the cure for cancer and immortality hang on just this one thread?

Whatever your views may be, the reality is that some of the world’s finest research scientists are working on that exact question and some would say it is only a matter of a decade or two before this is neither conjecture nor science fiction, but a reality to face up to. The changes that would take place in society even if life expectancy were to take a leap forward by say 10 or 20 years are enormous, but we should all be thinking that this is a distinct possibility.

From the dab of lanoline a generation ago to what I know hold in my hand as an anti aging skincare treatment is more than just a revolution – and I have no doubt in a few years I will be saying this cream will not just slow the aging process and reduce the visible signs of aging, making your face appear younger – but it will actually be younger.

But before that, let’s look back at how this whole engagement with life extension and anti-aging started. Mankind has always striven for longevity and mused about immortality – but the past 50 years has seen some dramatic steps in reality toward this goal.

Genesis

The thought of extending life has been on the mind of mankind for millennia. References to the search for ways to prolong life can be found as far back as the Epic of Gilgamesh.

Gilgamesh was reputedly the fifth king of the kingdom of Uruk, the modern-day Iraq, around 2500 BC. According to the Sumerian list of kings, he reigned for 126 years. The Torah or Old Testament records Methuselah as living over 900 years, with life spans measured in centuries apparently commonplace before the time of Noah.

Throughout the development of scientific thought from the Reformation onwards, scholars have applied themselves to solving this riddle and these endeavors continue today at the very leading edge of scientific progress.

Unraveling Secrets

As the secrets of our existence are unraveled in ever more minute detail, we are beginning to understand what it is that makes us grow from tiny babies into adults. We now know, for example, that cell functions slow down as the body ages and that production of certain substances required by the body to regenerate decrease or cease completely.

Skin, for instance, needs two substances to retain strength and firmness.
The production of these substances namely collagen (strength, tightness) and elastin (flexibility) decreases with age. The decreases in production together with other factors that include the threat of free radicals make the skin age and become wrinkly. Free radicals are essentially incomplete oxygen molecules causing destructive chain reactions within cells.

The same kind of thing happens in every cell, every tissue and organ around the human body. For example, people develop frown lines, crow’s feet and wrinkles. Nutrients are no longer absorbed easily and vital cell functions, hormones and other substances are produced at decreased rates resulting in the body aging.

A Brief History of the Life Extension Movement

Science has been looking for ways to slow down this process for centuries. The forming of life extension movements, however, did not really begin until around 1970.

➢ In this year, Denham Harman, the originator of the so-called ‘free radical theory of aging’, decided that an organization dedicated to the research and information sharing between scientists working in biogerontology (the field of science concerned with the biological aspects involved in the aging process) was needed. As a result, the American Aging Association was formed.

➢ In 1976, two futurists, Philip Gordon and Joel Kurtzman wrote a book on the research into extending the human lifespan. This popular volume was titled ‘No More Dying. The Conquest Of Aging And The Extension Of Human Life’.

➢ Kurtzman was then invited to speak at Florida’s House Select Committee (HSC) of Aging, which was chaired by Claude Pepper, an American politician and spokesman for the elderly. The aim of this talk was to discuss the impact on Social Security by life extension.

➢ In 1980, Saul Kent, a prominent activist in the field of life extension, published the book ‘The Life Extension Revolution’ and founded the nutraceutical (from ‘nutrition’ and ‘pharmaceutical’, in other words, a nutrition supplement) firm known as ‘The Life Extension Foundation’.

This foundation is a non-profit making organization promoting dietary supplements and publishing the periodical ‘Life Extension Magazine’. Kent was later involved in work relating to cryogenics. He was jailed in the course of this work over a dispute at one point, although charges were dropped at a later stage.

➢ In 1982, American health writer and life extension advocate Sandy Shaw and her co-writer, Durk Pearson, popularized the term ‘life extension’ even further with the bestseller ‘Life Extension: A Practical Scientific Approach’.

➢ Roy Walford, a gerontologist and life-extensionist, published ‘Maximum Lifespan’, another popular book on the subject. He and Richard Weindruch, his student, followed this up in 1988 with their summary on the research they had conducted into the ability to prolong the life of rodents through calorie restriction. The title of this book is ‘The Retardation of Aging and Disease by Dietary Restriction’.

Although this ability to extend life with calorie restriction had been known since the 1930’s, when gerontologist, biochemist and nutritionist Clive McCay did some research into the subject, it was the work of Walford and Weinbruch that gave solid scientific grounding to the McCay’s findings.

Walford’s scientific work was driven by a personal interest in life extension. He practiced calorie restriction as part of his own life and eventually died at the age of 80. The cause of his death was amyotrophic lateral sclerosis, a progressive motor neuron disease.

➢ A4M, the ‘American Academy of Anti-Aging Medicine’ was founded in 1992 to create a medical specialty for anti aging that was distinctly separate from geriatrics. This allowed scientists and physicians interested in this particular field of science to hold conferences and discuss the latest developments.

➢ The sci.life-extension, a Usenet group, was created by California-born author, philosopher and translator Brian M. Delaney. This represented an important development within the movement of life extension. It made it possible, for example, for the CR (Calorie Restriction) Society to be created.

➢ A more recent development is the proposal of Dr A. de Grey, a biogerontologist at Cambridge University. This proposal suggested that damage to cells, macromolecules, organs and tissues can be repaired with the help of advanced biotechnology. This is evident in hair restoration products, for instance.

More than Books

Although it would appear that most of the work revolving around life extension has been done solely by writing books or founding societies or organizations of some kind or another, the reality is that these books were written in response to or based on very specific, detailed scientific research that have yielded positive results.

They are no longer the works of hopeful minds, but the works of dedicated scientists who have spent their lives working on discovering facts about aging and trying to find ways to slow down, or even reverse the process.

Many breakthroughs have been made, and in many ways, we are already able to extend lives to a certain extent. The average lifespan of a human being is already far greater than it used to be as a result of medical, pharmaceutical and nutritional advances brought about by research and development.

The work continues, and scientists around the world are continually conducting research, comparing results, discussing options and making advances on our behalf.

Driving Forces behind the Development of the Life Extension Movement

What factors are driving this movement into ever greater efforts to find solutions to the extension of Life? The answer to this question actually includes a whole range of factors.

Expectations Have Risen

As the ‘baby boomer’ generation (born between 1946-1964) enters retirement age, expectations of this group are dramatically different from those of the preceding generations. They have greater expectations and desires to enjoy their life as pensioners to the fullest and for as long as is possible. This expectation covers not only length of life, but quality of life as well and this is not a passive request but an active and strident demand in many cases.

Pharmacology

Progress in pharmacology has led to a wide selection of drugs that allow people to live longer and fuller lives being developed over the last two decades or so. The work is still very much in progress and many more drugs are being developed daily.

One of the classic examples of a drug raising the quality of life for older individuals are erectile dysfunction treatments – notably Viagra, Cialis and Levitra. These drugs have dramatically reduced the number of fatalities or serious injury resulting from elderly men rolling out of bed, as well as a number of more qualitative benefits.

Advances in Genetics

Some of the latest scientific research and subsequent advances made in biotechnology and genetics are providing some hope that it may be possible to hold back some of the fundamental causes of aging.

As we outlined previously, chromosomes containing DNA strings are essentially capped with a binding substance known as telomeres. In effect, the telomeres are consumed during cell division and over time, they become shorter and shorter.

This was first observed by a scientist called Leonard Hayflick, and the process of limited cell division was subsequently named the Hayflick Limit. Advocates of life extension work on the thought that lengthening the telomeres through drugs or gene therapy may ultimately extend the Hayflick Limit and thereby fool the cells, and as such the body, into ‘thinking’ it is younger than it actually is.

Developments in Precision Manufacture

Advances made in the fields of nanotechnology, miniaturization, computer chips and robotics also provide hope for potentially life extending solutions.

In the 1970’s, a popular TV series starred Lee Majors as the ‘Six Million Dollar Man’? Science fiction then. Today, it is science fact. Millions of people now walk through life with artificial ankle, knee and hip joints and healthy feet. A generation ago, mass production of this kind of technology was a distant dream.

The same applies to many individuals with artificial limbs. Artificial legs used to be crude wooden contraptions that were just able to keep a person balanced. Today’s artificial limbs are almost fully functional.

The Blessings of Medical Progress

Who would have thought even 50 years ago that it would become possible to bypass a coronary artery, or even replace a heart completely? Yet there are hundreds of thousands, if not millions of individuals enjoying their lives after having this kind of surgery – few of whom would be alive just half a century ago.

Millions of people no longer have to wear glasses, because of the availability of laser surgery. This, too, was science fiction just a few years ago. Today, it is advertised next to shampoo in magazines and on TV.

In other words, science is moving rapidly towards not only extending life, but making the quality of these extra years better as well.

Is it Science, Science Fiction or Lunacy?

What should the average person believe? This question is almost as difficult to answer as finding solutions to extended life. Even among scientists, opinions are divided. Some do believe that extending the quality of life is as possible as extending life in general.

Others brush off the thought as un-scientific nonsense. This is often simply based on the fear of anything ‘new’ disturbing the status quo of established limits. Fortunately, real scientists do keep on looking, because if every single scientist had decided that some of the advancements already in medical, pharmaceutical and technological fields could not be possible, we would all still be dying at 30.

So where does that leave us?

There is no doubt what-so-ever that there are many charlatans out there trying to make a quick buck out of people’s desire to retain their youth. Even today, many products being sold in their millions are essentially non-effective – often given fantastic names and have the most bewildering ingredients to make them look scientific to consumers and justify their cost.

But the facts are while many advancements are being made and research points to the possibility of eventually finding the key to maintaining youth for longer, the scientific community is still warning the public that many of the products being sold today are unreliable to say the least.

➢ Although food supplements may assist in keeping a body healthier – something that can often be achieved by simply adopting a healthier life style and diet – there is as yet no categorical and undeniable proof that they slow down aging as such.

➢ The same goes for many hormone treatments. Although they may have a short term effect of some kind, it is not yet scientifically proven that they will actually work in the long run. The fear that it may not work is based on the fact that taking hormones, a good example is the hormonal acne treatment, will ultimately actually slow down the body’s own production of these hormones.

In addition, many treatments may have potential (and yet unknown) side effects in the long run that could be harmful to the user’s health. This includes the fears that such hormone treatments could increase the risk of cancer, diabetes and other major illnesses.

➢ Other ideas, like the calorie restriction method, are working for rodents. In fact, studies conducted with rats on 30 to 50 per cent restricted diets have shown to almost double the life span of rats.

Similar studies conducted on primates have also shown tendency to extend life to a certain extent and prevent a list of age related illnesses. There are as yet no studies on humans, although some are actually living on calorie restricted diets. Whether this will prolong their lives, however, is a question of having to wait and see.

The theory is that by reducing calorie intake, the metabolism of the body is slowed down, thereby slowing the aging process as well. Nutritionists say there is a certain amount of calories a body of a certain size and weight needs to have to maintain health. Reducing this amount by up to 50 per cent is hardly a good idea in the long term.

Time will tell, as they say, but how will anyone be able to tell the difference? If a person lives to the age of 80, is this because they are on this diet or would they have lived to this age anyway?

Where Will This Lead?

Many believe there is realistic hope and expectation of making significant strides in the area of longevity within the next two decades. This group typically believes the answer will ultimately lie within genetics and biotechnology. It is too early to make definite predictions, but the research so far shows promise and, as mentioned earlier, some of the results of this research are already being used in certain treatments to improve patients’ lives.

At present, overall aging is difficult to slow down, to say the least. Some products indicate they will assist in maintaining overall health/longevity, but the area we are seeing the first commercial products being developed is in the area of skin care and given the size of this market, it is likely that this will continue to be the weather-vane of longevity treatments.

Science or Snake Oil?

It will be difficult to tell these two apart for many years. Charlatans are likely to about, because it is difficult to disprove many theories easily. Equally difficult will be positive proof from those with an ethical perspective on the trail of a real breakthrough, as products based on valid research and using technology or ingredients that will actually have an effect rarely promise overnight results. This is something that anyone looking to find improved youthful looks, etc, will have to bear in mind. None of these products can perform miracles. Even the best of them will take time and regular use in order to achieve the desired effect.

The bottom line is that where we stand now, we can be sure there are some things which are ineffective or even harmful; there are some that show some promise and there are some that are starting to cross the line of being able to demonstrate results – albeit modestly at this point.

In the meantime, it is wise to research products very carefully and to refuse to be baffled by weird and wonderful sounding ingredients or fantastic sounding promises of instant youth. Regeneration will take time – let’s face it, it has taken a lifetime to get to this point, turning back the clock can never be possible over night.

Skin Care and the Life Extension Movement

One may well ask just what all this, and in particular the life extension movement as such, could possibly have to do with skin care, health and beauty products. The fact is, much of the research into life extension is resulting in new approaches to skin care as a kind of by-product.

A greater understanding of how genetics and cellular processes affect the aging and condition of skin allows these research and development teams to investigate different compounds, their compatibility with human cells and genetic make up.

Many compounds found in nature are not just compatible to human skin but in fact the skin cells actually have natural receptors for these compounds. Because life extension research has discovered these receptors, skin care developers can now use this knowledge and create the formulae for their products to provide maximum effect.

Another skin care ‘by-product’ of life extension research is the use of nanotechnology. The use of nanotechnology, or, to be more precise, nanoparticles, has had a huge impact on the way nutrients and other components of skin care products are being delivered to the skin cells. In some ways, nanotechnology has already revolutionized skin care. It is now possible to use active ingredients previously difficult to effectively deliver to the skin, as well as making old, proven ingredients even more effective. Some ingredients used in cosmetics for hundreds, if not thousands of years by certain cultures can now be even more effectively used to improve skin condition and maintain a healthy, youthful look.

Even the moisturizing effect of skin care products can be improved with nantechnology. For this effect, so-called nanosomes are used. Nanosomes are small, pocket-like particles that melt or disintegrate on skin contact. By doing this, the moisturising effect is accelerated, assisting the skin faster and more efficiently.

Nanotechnology plays a key part not only in slowing the aging of skin, but is believed to actively assist in repairing and healing skin cells and tissue.

Another breakthrough in life extension research that is beginning to make itself felt in skin care products is the research into stem cells. Stem cells are elements of all life, plant, animal and human. Stem cells have two properties other cells do not have. These properties are the ability to develop into any kind of cell type and the ability to divide almost indefinitely. The use of plant stem cell extracts in skin care is likely to become one of the next ‘big things’ in the industry. And prepare for the debate when human stem cells are proposed as part of an anti-aging skincare regime, as will inevitably occur!

One thing we can be certain of, is that science will continue to search for answers to the question of life extension, and business will drive the commercialization of discoveries. But whether these lead us to a utopian future or potentially a minefield of strife as we debate who will use and who will benefit from these new godlike powers. In the meantime, at a practical level in the skincare, health and beauty industry we remain hopeful and expectant we will see the emergence of products that not only promise results, but produce them.

David Christensen is a veteran of Asia Pacific business, currently residing in Bangkok, Thailand and heading up the business he was a co-founder of, Royal Siam Natural Health & Beauty – who can be located at [http://www.royalsiam.asia], and the information supporting site at [http://www.royalsiam.info]. Royal Siam was established after careful planning in early 2011, spending 2011 concentrating on building the necessary business infrastructure and concentrating on the domestic Thai market. Early in 2012 Royal Siam launched its international website and online store, and in April 2012 publicly declared the ambition to be among the world’s top 20 premium health and beauty brands by the year 2020. Royal Siam is a unique business, operating in the premium skincare, anti aging, and related fields. At its core, one mission is to commercialize and bring to a global market the immense wealth of knowledge about the healing and beneficial properties of Thai and South East Asian plants – a knowledge base carefully built up over the last thousand years. At the same time, the mission is to bring to market the very latest in scientific advances in the area of anti aging… resulting in the unique position of having a Thai heritage and offering the best of nature, tradition, and science.

Article Source: http://EzineArticles.com/expert/David_D_Christensen/1317312

The Programmed Cellular Death Approach to Anti-Aging Treatment

May 8, 2016 by · Comments Off on The Programmed Cellular Death Approach to Anti-Aging Treatment
Filed under: General 

Modern anti-aging treatment is built on a common base of knowledge that I will quickly review. Biochemistry and molecular biology tell us there are many types of chemical reactions going on in the human body. We know that it is the genetic information programmed inside our cellular DNA that defines what reactions occur. Genetic information, expressed in regulated ways, builds the body’s proteins and enzymes, and controls how enzymes carry out the cell’s biochemical reactions.

This information, contained in the DNA of our genome, consists of many thousands of long, often repetitive, sequences of base pairs that are built up from four basic nucleotides. Human genome mapping has shown there are over 3 billion base pairs in our DNA. It is estimated they contain some 20,000 protein-coding genes. All body functions are controlled by the expression of the genes in our genome. The mechanisms controlling the aging process are believed to be programmed into our DNA but only a fraction of the biochemical reactions related to the aging process have been looked at in any detail. Cellular aging is a very complex process and many of its low level operating details have yet to be discovered.

Anti-aging theory has consolidated itself along two lines of thought: the programmed cellular death theory and the cellular damages theory. The programmed death theory focuses on the root causes of aging. The cellular damages theory looks at the visible aspects of aging; i.e. the symptoms of aging. Both theories are correct and often overlap. Both theories are developing rapidly as anti-aging research uncovers more details. As works in progress these theories may take years to complete. This broad characterization also applies to the currently available types of anti-aging treatments.

The programmed death theory of aging suggests that biological aging is a programmed process controlled by many life span regulatory mechanisms. They manifest themselves through gene expression. Gene expression also controls body processes such as our body maintenance (hormones, homeostatic signaling etc.) and repair mechanisms. With increasing age the efficiency of all such regulation declines. Programmed cellular death researchers want to understand which regulatory mechanisms are directly related to aging, and how to affect or improve them. Many ideas are being pursued but one key area of focus is on slowing or stopping telomere shortening. This is considered to be a major cause of aging.

With the exception of the germ cells that produce ova and spermatozoa, most dividing human cell types can only divide about 50 to 80 times (also called the Hayflick limit or biological death clock). This is a direct consequence of all cell types having fixed length telomere chains at the ends of their chromosomes. This is true for all animal (Eukaryotic) cells. Telomeres play a vital role in cell division. In very young adults telomere chains are about 8,000 base pairs long. Each time a cell divides its telomere chain loses about 50 to 100 base pairs. Eventually this shortening process distorts the telomere chain’s shape and it becomes dysfunctional. Cell division is then no longer possible.

Telomerase, the enzyme that builds the fixed length telomere chains, is normally only active in young undifferentiated embryonic cells. Through the process of differentiation these cells eventually form the specialized cells from which of all our organs and tissues are made of. After a cell is specialized telomerase activity stops. Normal adult human tissues have little or no detectable telomerase activity. Why? A limited length telomere chain maintains chromosomal integrity. This preserves the species more than the individual.

During the first months of development embryonic cells organize into about 100 distinct specialized cell lines. Each cell line (and the organs they make up) has a different Hayflick limit. Some cell lines are more vulnerable to the effects of aging than others. In the heart and parts of the brain cell loss is not replenished. With advancing age such tissues start to fail. In other tissues damaged cells die off and are replaced by new cells that have shorter telomere chains. Cell division itself only causes about 20 telomere base pairs to be lost. The rest of the telomere shortening is believed to be due to free radical damage.

This limit on cell division is the reason why efficient cell repair can’t go on indefinitely. When we are 20 to 35 years of age our cells can renew themselves almost perfectly. One study found that at the age 20 the average length of telomere chains in white blood cells is about 7,500 base pairs. In humans, skeletal muscle telomere chain lengths remain more or less constant from the early twenties to mid seventies. By the age of 80 the average telomere length decreases to about 6,000 base pairs. Different studies have different estimates of how telomere length varies with age but the consensus is that between the age of 20 and 80 the length of the telomere chain decreases by 1000 to 1500 base pairs. Afterwards, as telomere lengths shorten even more, signs of severe aging begin to appear.

There are genetic variations in human telomerase. Long lived Ashkenazi Jews are said to have a more active form of telomerase and longer than normal telomere chains. Many other genetic differences (ex.: efficiency of DNA repair, antioxidant enzymes, and rates of free radical production) affect how quickly one ages. Statistics suggest that having shorter telomeres increases your chance of dying. People whose telomeres are 10% shorter than average, and people whose telomeres are 10% longer than average die at different rates. Those with the shorter telomeres die at a rate that is 1.4 greater than those with the longer telomeres.

Many advances in telomerase based anti-aging treatments have been documented. I only have room to mention a few of them.

– Telomerase has been used successfully to lengthen the life of certain mice by up to 24%.

– In humans, gene therapy using telomerase has been used to treat myocardial infarction and several other conditions.

– Telomerase related, mTERT, treatment has successfully rejuvenated many different cell lines.

In one particularly important example researchers using synthetic telomerase that encoded to a telomere-extending protein, have extended the telomere chain lengths of cultured human skin and muscle cells by up to 1000 base pairs. This is a 10%+ extension of telomere chain length. The treated cells then showed signs of being much younger than the untreated cells. After the treatments these cells behaved normally, losing a part of their telomere chain after each division.

The implications of successfully applying such techniques in humans are staggering. If telomere length is a primary cause of normal aging, then, using the telomere length numbers previously mentioned, it might be possible to double the healthy time period during which telomere chain lengths are constant; i.e. from the range of 23 to 74 years to an extended range of 23 to 120 or more years. Of course this is too optimistic because it is known that in vitro cultured cells are able to divide a larger number of times than cells in the human body but it is reasonable to expect some improvement (not 50 years but say 25 years).

We know that telomerase based treatments are not the final answer to anti-aging but there is no doubt that they can, by increasing the Hayflick limit, extend or even immortalize the lifespan of many cell types. It remains to be seen if this can be done safely done in humans.

Telomerase based treatments are only a partial answer to anti-aging. Please carefully research any anti-aging supplements based on this line of treatment. Through my articles and website I want to help you maintain your good health for the next 10 to 25 years. My hope is that within time period the fruits of anti-aging research will become available to everyone.

Article Source: http://EzineArticles.com/9227048

Part Four: Current and Future Anti-Aging Treatments

May 1, 2016 by · Comments Off on Part Four: Current and Future Anti-Aging Treatments
Filed under: General 

As previously noted, many anti-oxidants are essential nutrients. Natural anti-oxidants, like vitamin C and E, work synergistically. Anti-oxidants may be more effective if obtained from a diet rich in fruits and vegetables. Nutritionists recommend eating 6 or more daily servings of anti-oxidant rich fruits and vegetables. Everyone agrees the use of antioxidant supplements for anti-aging may be helpful, but there is no agreement on what the most effective supplement dosages should be.

Anti-aging medicine acknowledges that stress of all kinds causes aging but has not yet developed individualized treatment for this. There are countless sources of internal and external stress and individual stress levels vary greatly. One overlooked cause of internal stress is improper hydration. Water is essential in for the correct operation of many internal functions. Too little or too much water causes age producing stress. When one is old (80+) thirst perception declines and dehydration can easily set in. Other overlooked sources of stress are antioxidants themselves. High doses (or doses above certain yet unspecified amounts) of supplemental anti-oxidants are a known cause of stress.

To be helpful, antioxidant supplements must prevent other types of stress more than the stress they themselves create. Knowing the correct supplement dosages that can do this is an essential part of anti-aging treatment. A healthy young person in his twenties, who is properly nourished, will have less internal stress that an older individual in his sixties. For a young individual, lower amounts of antioxidants may be safer than higher amounts. A older person, whose many internal homeostatic mechanisms are less able to deal with internal stress, may benefit more from higher amounts of antioxidants. Theoretically an anti-oxidant based course of anti-ageing treatment will slow the rate at which cellular damage occurs. Cells will become “sick” more slowly. Over time, as fewer sick cells are replaced at a slower rate, the number of cells retaining longer telomere chains will be higher. You can then reasonably expect this to result in an increase in life expectancy. For now the recommended but imprecise approach to decrease the rate at which cellular damage occurs is to increase your per day intake of anti-oxidant rich fruits and vegetables, to slightly increase your intake of antioxidants, and to take various vitamins and small amounts of anti-aging supplements on a daily basis. One study has shown taking a good multivitamin supplement is associated with longer telomere length.

Ideally anti-aging treatment should to be fine tuned for each individual. The key here would be to measure and minimize the cumulative effects of different kinds of stress on an individual basis. Easily measurable practical bio-markers for various types of stress do not yet exist or are not being used. When they are used it will be easy to customize individual antioxidant dosages so that everyone have “optimum” levels throughout their life. “Optimum” levels would maintain a safe reserve of protective antioxidants in the body.

Next I will briefly discuss the most popular nutrients associated with anti-aging. The most popular of the anti-oxidants, vitamins, and nutrients often associated with good health and anti-aging include: beta-carotene (vitamin A), vitamin C, vitamin E, various Flavonoids,Omega-3 and omega-6 fatty acids, Co-enzyme Q10, Lycopene, Selenium.

There are dozens of supplements that are known to effectively treat specific symptoms of old age. A few of the better known supplements include: DMAE, Acetyl-l-carnitine, L-carnosine, Alpha Lipoic Acid, DHEA, L-arginine, and melatonin

Good food contains some of the anti-oxidants previously mentioned. A few other popular foods associated with anti-aging include: Green Tea, turmeric, and red wine.

All of the above have unique biological properties and, in my opinion, are “good” for you if taken in small or moderate amounts. Some (ex. vitamin C) may also be “good” for you in larger amounts. Various studies on each of these may conflict with each other. You need to carefully research each substance on your own but researchers have already found several nutrients to be associated with longer than average telomere lengths. These include: Green Tea, Omega-3, Vitamins A, C, D, and E.

Vitamin E has been associated with telomere lengthening anti-aging properties.

Green tea contains many antioxidants, including vitamin C, E and flavenoids.Flavenoids form a large antioxidant class (including catechins and quercetin) that has many anticarcinogenic, antihypercholesterolemic, antibacterial, (helps prevent dental caries), and anti-inflammatory properties. The leaves of the tea plant are rich in polyphenols. The consumption of 3 cups or more of green tea daily has been associated with longer than average telomere length.

The Omega-3s are essential long-chain polyunsaturated fatty acids that are anti-inflammatory and help prevent heart disease, stroke, memory loss, depression, arthritis, cataract, cancer. Omega-3s slow down the shortening of telomeres; i.e. they may protect against aging on a cellular level.

Vitamin C is an abundant internal water soluble antioxidant that protects cellular components against free-radical formation caused by pollution and cigarette smoke. Many studies have associated high vitamin C intakes with lower rates of cancer of the mouth, larynx and esophagus. Vitamin C has shown promise in treating premature aging and possibly aging itself.

Due to limitations on the number of links I can incorporate into this article I could not provide more reference links supporting the preceding paragraphs. If interested please email me at the email address shown at the end of this article and I will forward them to you.

The sooner you start some sort of anti-aging treatment the better but it is never too late to start. All real treatments will help you maintain a longer than average average telomere chain length.

The goal of the programmed death theory of aging is to address the root causes of aging. This goal includes attempts to slow or reverse the telomere shortening process. Two such treatments are: TA 65 and human genetic engineering.

TA 65 is a telomerase activating product produced and marketed by Sierra Sciences. The key ingredient in TA 65 is Astragalus, a plant extract known to have telomerase activation properties. The product may work but I do not recommend it for several reasons. TA 65 is too expensive for the average person. A number of expensive health spas incorporate TA 65 in their programs. Again these are financially beyond the reach of the average person. The marketing tactics of Sierra Sciences have been questioned by many and there are law suits pending against TA 65.

The big issue I have with TA 65 is one of scientific honesty. The company genetically engineered mice that allowed telomerase to be switched off and on at an early age. TA 65 was able to switch telomerase back on in these mice and allowed them to live normal lives. http://www.nature.com/news/2010/101128/full/news.2010.635.html

Using this to show how effective TA65 treatment is, is dishonest. This is not how telomerase normally works and there was no real extension of the lifespan beyond what it would have been without the genetic modification. In normal mice the effects of TA65 were temporary and little or no life extension was seen. http://www.thedailybeast.com/articles/2011/04/11/anti-aging-pill-new-study-on-ta-65-sparks-controversy.html

Human genetic engineering is the real answer to fighting and defeating aging. It can directly address the root causes of aging. Advances in this area (ex. CRISPR) allow DNA base pairs to be inserted or deleted at specific place in our DNA. This means the human genome can now be precisely edited as needed. The lifespan of old mice has been modestly increased using telomerase gene therapy. In humans gene modification therapy has frequently been used for various medical problems. On September 15, 2015, Elizabeth Parrish was the first human to undergo anti-aging gene therapy. Anti-aging treatments will rapidly advance as our knowledge of the specifics of the human genome grows.

Current general social-political attitudes seem to be favoring the further development of anti-aging research. There are no international recognized political programs to stop aging or extend life but since 2012 a few pro-immortality political parties have sprung up. Their aim is to support anti-aging and life extension research, and to help provide access to advances in these areas to everyone. Among the numerous organizations supporting anti-aging research, the SENS (Strategies for Engineered Negligible Senescence) organization has come up with an anti-aging research plan. They want to develop anti-aging therapies to repair most forms of cellular damage. SENS, is a charitable organization. Any anti-aging advances resulting from funding it provides will become readily available public knowledge. In addition to the normal scientific research there is the $1,000,00 Palo Alto Longevity Prize that is being offered to anyone who can come up with an effective anti-aging treatment.

As of 2015, all known anti-aging treatments are only partially effective. Depending on when one starts a comprehensive anti-aging program, one can probably extend one’s life by 10 to 25 years. Researchers from the Harvard School of Public Health estimated that an anti-aging lifestyle can add 24.6 more productive years to one’s lifespan. Anti-aging knowledge increases at a rate of about 10 times every 10 years. This probably means that for many of us there is more than enough time to reap the anticipated benefits in anti-aging research. One day soon, aging, like many other diseases, will be cured. While we wait for those anti-aging technological singularities to occur the name of the game is to ensure we stay healthy long enough repeat their benefits.

As a former engineer I have a strong affinity to all sciences including biology.

My interests include following advances in the fields of anti-aging, health and nutrition. Rapid advances in these areas will vanquish the disease we call aging.
Through my articles and website I want to help you maintain your good health for the next 10 to 25 years. I believe this can be done by a daily program that includes moderate exercise, a healthy diet that includes vitamins and related supplements, and taking advantage of any advances in related research. My hope is that within the next 25 years or less, the fruits of anti-aging research will become available to everyone.

Article Source: http://EzineArticles.com/9239681

What Makes Someone a Senior Citizen? by Lynn Dorman, Ph.D.

April 18, 2013 by · Leave a Comment
Filed under: Articles 

Good question!

Developmental Psychologists have long used either ages or stages to define  segments of the population. Many developmental textbooks are divided into  chapters based on one or the other of these definitions.

Age definitions are ones that use numbers – such as: being 65 or older means  you are a senior citizen; or all over 55 get a senior citizen discount.

Stage definitions are usually feeling and behavior related – along the lines  of: “you are only as old as you feel or act.”

Over the last few decades, as we learn more and more about the later  stages/ages of the lifespan, the thinking about aging is changing – and so are  the textbooks. But the definitions are still stuck in the past.

The field of Developmental Psychology is itself aging – as are the original  developmental psychologists – and more information is becoming known and  understood about the lifespan.

Add to this that we are living longer. In 1940, the average life expectancy  at birth in the USA was 62.9 years; in 1960 it was 69.7; by 1980 it was 74.1 and  in 2000 it was 77.2. [The statistics differ by sex and ethnicity but these are  the averages for all persons.]

Average only is a middle figure. Half die before and half after the ages  cited. And if one lives past infancy, life expectancy increases and it increases  every year one is still alive. So those who were born in 1940, and are obviously  now well past 62.9, have a far different life expectancy than when they were  born. That expectancy is now somewhere into their mid 80s.

So as to defining what makes you a senior citizen? It is often left up to the  language or stereotypes we use and some legal definitions.

Most jurisdictions rely on when you can start collecting social security  benefits to define what is their senior population. Eligibility for full Social  Security benefits will increase to age 67 for those born in 1960; yet as we can  still sign up for Medicare at age 65 – 65 seems still to be the “age” definition  of senior citizen.

Will that change? It might…but not for those who are already at or near 65.  We ARE labeled senior citizens.

And what about behavioral definitions – the stages aspect?

That is up to us. We can continue to do what we have been doing – living life  to the fullest and not becoming the stereotypes many have about senior  citizens.

We are who we are – and are the ages we have accumulated!

If we let someone else’s characterizations of “senior-ness” define us or our  behavior – then we are falling prey to their stereotypes. Create your own  definition of senior.

I am of the thought that we are only as old as we feel and act! So feel  and act young!

You may still be called a “senior” but you’ll wind up confounding a lot of  people.

I invite you to read more of my take on aging at http://growolderbetter.com – and where you can sign up for  even more tidbits.

From Lynn Dorman, Ph.D., a developmental psychologist who was around way back  then and is now a 70-year-old-senior-citizen who is still figuring out what she  will do when she grows up.

Article Source: http://EzineArticles.com/?expert=Lynn_Dorman,_Ph.D.

Nevada-Senior-Guide Nevada Aging and Disability Services Division

August 10, 2011 by · Leave a Comment
Filed under: Support Services 

http://www.nvaging.net/

The Aging and Disability Services Division (ADSD) in the State of Nevada, Department of Health and Human Services, represents Nevadans aged 60 years and older and those with disabilities.

Mission Statement The Aging and Disability Services Division provides leadership and advocacy in the planning, development and delivery of a high quality, comprehensive support service system across the lifespan. This allows all of Nevada’s elders, adults and children with disabilities or special health care needs to live independent, meaningful, and dignified lives in the most integrated setting appropriate to their needs. Developmental Services

State of Nevada Aging and Disability Services Division (ADSD)

Programs/Services

 

Advocate for Elders

Advocacy, assistance, information and referral to frail seniors, who are 60 years of age or older, primarily homebound and living in the community, and their caregivers.

Aging and Disability Resource Centers (ADRCs)

Provides citizen-centered “one-stop” entry points into the long-term support system. Serves individuals in need of long-term support, caregivers, and those planning for future long-term support needs.

Assisted Living (AL) Waiver

Assisted living supportive services to eligible individuals in a residential facility as an alternative to nursing home placement.

 

Community Options Program for the Elderly (COPE)

Non-medical services to older persons to help them maintain independence in their own homes as an alternative to nursing home placement. Similar to the HCBW Program.

 

Disability Rx (External link) Assistance with the cost of prescription medicines to qualified individuals with disabilities.

 

Disability Services (External link)The Office of Disability Services provides resources at the community level which promote equal opportunity and life choices for people with disabilities through which they may positively contribute to Nevada.

Elder Protective Services (EPS)

For persons 60 years old and older who may experience abuse, neglect, exploitation, or isolation.

 

Grants

Information for current and/or prospective grantees.

 

Home and Community Based Waiver (HCBW formerly CHIP)

Non-medical services to older persons to help them maintain independence in their own homes as an alternative to nursing home placement.

 

Homemaker Program

General housekeeping, limited meal preparation, shopping, laundering, errands, standby assistance with bathing, and home management services.

 

IDEA Part C Office

Provides oversight of Part C (early intervention services) of the Individuals with Disabilities Education Act (IDEA).

 

Long Term Care Ombudsman

Addresses issues and problems faced by residents in long term care facilities, which includes residential facilities for groups.

 

Senior Medicare Patrol (SMP)

The goal of the SMP program is to empower seniors to prevent Medicare/health care fraud through outreach and education.

 

Senior Rx

Nevada’s plan to provide Nevada seniors relief from the high cost of prescription medicine.

 

Senior Tax Assistance/Rent Rebate Program

This program is no longer available.

 

State Health Insurance Assistance Program (SHIP)

Medicare Counseling Information

Counseling and assistance to Medicare Beneficiaries in Nevada, utilizing a statewide network of volunteers.

 

Taxi Assistance Program (TAP)

Discounted taxicab fares to seniors and persons with disabilities in Clark County. (Washoe County also has a program of this type.

 

 

Waiver for the Elderly in Adult Residential Care (WEARC)

Non-medical services in a group care setting to offer individuals a less expensive alternative of supervised care in a residential setting.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Senior Industry Network Group Events

    Monthly SING Meetings are held the first Thursday of every month at our NEW location below:

    Desert Canyon - HealthSouth
    9175 W. Oquendo Rd.
    Las Vegas, NV 89148

    S.I.N.G. Agenda:
    - Coffee and bagels will be served
    - A time to show gratitude by thanking those who have sent you referrals
    - Announcements around the room
    - One minute commercials
    - Open Discussion on topics of Self Empowerment

    * When? The 1st Thursday of every month. Networking starts at: 8:00am | Meeting starts at: 8:30am

    * How Much? It’s free!